Hugh Laurie - Dr. Gregory House
Lisa Edelstein - Dr. Lisa Cuddy
Robert Sean Leonard - Dr. James Wilson
Omar Epps - Dr. Eric Foreman
Jesse Spencer - Dr. Robert Chase
Olivia Wilde - 13-as
Peter Jacobson - Taub
Amber Tamblyn - Martha M. Masters
Jennifer Morrison - Dr. Allison Cameron
Kal Penn - Kutner
Anne Dudek - Amber Volakis
David Morse - Michael Tritter
Sela Ward - Stacy Warner
Currie Graham - Mark Warner
Chi McBride - Edward Vogler
Stephanie Venditto - Brenda Previn
Andy Comeau - Brennan
Charles S. Dutton - Rodney Foreman
Zeljko Ivanek - Jason